Molecular and Genetic Epidemiology I

EPI 217 Winter 2019 (2 units)
Course Directors: John S. Witte, PhD
Department of Epidemiology & Biostatistics
Thomas J. Hoffmann, PhD
Assistant Professor
Department of Epidemiology & Biostatistics


This course introduces the concepts, principles, and use of molecular and genetic methods in epidemiologic and clinical research. Specifically, students will learn about: common molecular and genetic measures; linkage and association approaches to searching for disease-causing genes, and their interaction with environmental factors; pharmacogenomics; and ethics in genetics-based research. Ultimately, students will develop a framework for interpreting, assessing, and incorporating molecular and genetic measures in their area of research.


Designing Clinical Research (EPI 202). Exceptions to this prerequisite may be made with the consent of the Course Director, space permitting.

Course Directors:

John Witte, PhD
Phone: 415-502-6882


Thomas Hoffmann, PhD
Phone: 415-476-2475

Teaching Assistant:

Maria Elizabeth Mercado, MD
Phone: 415-502-6882


Course content will be delivered through weekly interactive lectures. These will take place on Tuesdays from 1:00 PM to 3:00 PM, Jan. 8 to Mar. 19

All course materials and handouts will be posted on the course's online syllabus.


Genetic Epidemiology: Methods and Applications, by Melissa A. Austin. Centre for Agriculture and Biosciences International (CABI), 2013.

Books may be purchased either through the publisher or a variety of commercial venues (e.g.,


Grades will reflect scores on:

  • homeworks (60% total);
  • class participation (10%); and
  • the final project (30%).

Homework should be turned in on the due date by noon (Mondays).

Students not in full-year TICR Programs who satisfactorily pass all course requirements will, upon request, receive a Certificate of Course Completion.

UCSF Graduate Division Policy on Disabilities


This course is sponsored by the Training in Clinical Research (TICR) Program, and space is limited. Preference is given to UCSF-affiliated personnel. We regret that auditing is not permitted.

To apply for this course, please fill out and submit the application below. Please see our fees page for cost information. The deadline for application is December 21, 2018. Only one application needs to be completed for all courses desired during the quarter.

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