At UCSF we began clinical research training over two decades ago with the Summer Course in Designing Clinical Research (the “Hulley Course”, directed by Dr. Stephen Hulley). The Summer Program has been expanded over the years with the addition of companion courses to the Designing Clinical Research course. The program has also undergone various name changes (e.g., ORACLE), and is currently known as the Summer Clinical Research Workshop. In 1992 we began offering the Advanced Training in Clinical Research (ATCR) Certificate Program, a year-long sequel to the Summer Program for scholars interested in additional instruction in the methods of clinical research. In 1999, our programs were greatly expanded as a result of being awarded a NIH K-30 Clinical Research Curriculum Award, and we adopted the Training in Clinical Research (TICR) Program as our new name. In particular, this expansion included a more rigorous curriculum in the ATCR Certificate Program, and in 2002 the enrollment of scholars into our two-year Master's Degree Program in Clinical Research. This specialized degree program in clinical research is the first of its kind in the University of California system.

In 2004, we were awarded an NIH K12 grant to begin a Multidisciplinary Clinical Research Scholars Program as part of the NIH Roadmap Initiative. This program provides financial support for salary, clinical research training, and conduct of research to a select group of post-doctoral fellows and faculty members for a period of 2 to 5 years.

In 2006, 2010 and 2016, UCSF received a Clinical and Translational Sciences Award from NIH to create the Clinical and Translational Sciences Institute (CTSI) that now includes the TICR program, KL2 career development award program, and TL1 training program.